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As GLP-1 based medications, they work with your physiology to quiet hunger, slow stomach emptying, and steady blood sugar, so eating less feels possible rather than punishing

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The pattern of results, particularly the amplification of benefit at higher weight loss thresholds, is consistent with the hypothesis that HRT restores a metabolic environment that makes GLP-1 therapy more effective: improving insulin sensitivity, preserving lean mass, reducing the inflammatory burden that blunts metabolic responsiveness, and supporting the mitochondrial function that underlies energy regulation